Common Symptoms Of Magnesium Deficiency In Females

Kobi Nathan
Magnesium deficiency in females can present with a variety of symptoms that are often nonspecific and can be easily overlooked.
Common symptoms include weakness, muscle cramps, and twitching.
These neuromuscular symptoms are due to magnesium's role in muscle function and nerve transmission.[2-3]
Additionally, magnesium deficiency can lead to confusion and irritability, reflecting its importance in cognitive function and emotional regulation.
Cardiovascular symptoms such as irregular heartbeat and hypertension may also occur, given magnesium's role in cardiac excitability and vasomotor tone.[4][6]
In severe cases, hypomagnesemia can result in seizures and tremors, highlighting the critical role of magnesium in neuromuscular conduction.
Furthermore, chronic magnesium deficiency has been associated with osteoporosis and bone fragility, due to its involvement in calcium metabolism and bone health.[2-3][7]
Magnesium deficiency is particularly prevalent among pregnant women and those with hormone-related conditions, where it can exacerbate symptoms such as edema, previous pregnancy complications, and infections.
Routine screening for magnesium levels in these populations is recommended to prevent and manage these symptoms effectively.[7]
Overall, maintaining adequate magnesium levels is essential for preventing these diverse and often debilitating symptoms in females.

References:
  1. Magnesium Disorders. Touyz RM, de Baaij JHF, Hoenderop JGJ. The New England Journal of Medicine. 2024;390(21):1998-2009. doi:10.1056/NEJMra1510603.  
  2. Magnesium Blood Test. National Library of Medicine (MedlinePlus)
  3. Contemporary View of the Clinical Relevance of Magnesium Homeostasis. Ayuk J, Gittoes NJ. Annals of Clinical Biochemistry. 2014;51(Pt 2):179-88. doi:10.1177/0004563213517628.
  4. Magnesium in Aging, Health and Diseases. Barbagallo M, Veronese N, Dominguez LJ. Nutrients. 2021;13(2):463. doi:10.3390/nu13020463.
  5. The Multifaceted and Widespread Pathology of Magnesium Deficiency. Johnson S. Medical Hypotheses. 2001;56(2):163-70. doi:10.1054/mehy.2000.1133.
  6. Magnesium in Prevention and Therapy. Gröber U, Schmidt J, Kisters K. Nutrients. 2015;7(9):8199-226. doi:10.3390/nu7095388.
  7. Risk Factors and Comorbidities Associated With Magnesium Deficiency in Pregnant Women and Women With Hormone-Related Conditions: Analysis of a Large Real-World Dataset. Orlova S, Dikke G, Pickering G, et al. BMC Pregnancy and Childbirth. 2021;21(1):76. doi:10.1186/s12884-021-03558-2.
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