Overview

Lactobacillus acidophilus, Bifidobacterium lactis, Lactobacillus plantarum, and Lactobacillus paracasei are probiotics with various health benefits supported by clinical (human) and preclinical (animal) studies.

Lactobacillus acidophilus has been shown to possess anticarcinogenic, hypocholesterolemic, and antagonistic activities against intestinal and food-borne pathogens.

It can enhance the intestinal epithelial tight junction barrier and protect against intestinal inflammation through a Toll-like receptor 2-dependent mechanism.

Additionally, it has immunomodulatory properties, enhancing both innate and adaptive immunity.

Bifidobacterium lactis (also known as Bifidobacterium animalis subsp. lactis) is well-documented for its beneficial effects on gastrointestinal health and immune function.

It has been shown to improve bowel function, protect against diarrhea, and reduce the side effects of antibiotic treatment, such as antibiotic-associated diarrhea.

It also supports a healthy gastrointestinal microbiota and enhances the body's resistance to common respiratory infections.

Lactobacillus plantarum exhibits several therapeutic benefits, including improving gastrointestinal symptoms, enhancing oral health, and reducing systemic inflammation.

Specific strains, such as L. plantarum 299v, have been effective in managing gastrointestinal disorders and reducing pathogenic colonization.

L. plantarum also has antioxidant and antimicrobial properties, and it can regulate the intestinal microbiota composition positively.

Lactobacillus paracasei has been shown to have cardiometabolic benefits, such as improving endothelial function and reducing remnant cholesterol levels in subjects with metabolic syndrome.

It also exhibits anti-inflammatory and antimicrobial activities, with high gut adhesion ability and gastrointestinal tolerance.

Additionally, it has been effective in managing blood cholesterol and pressure, preventing gastric mucosal lesion development, and alleviating allergies.

These probiotics offer a range of health benefits, including gastrointestinal health, immune modulation, and metabolic improvements, supported by various clinical studies and reviews

References:

 Lactobacillus Acidophilus Induces a Strain-Specific and Toll-Like Receptor 2-Dependent Enhancement of Intestinal Epithelial Tight Junction Barrier and Protection Against Intestinal Inflammation. Al-Sadi R, Nighot P, Nighot M, et al. The American Journal of Pathology. 2021;191(5):872-884. doi:10.1016/j.ajpath.2021.02.003.

The Immunomodulatory Effects of Lactic Acid Bacteria for Improving Immune Functions and Benefits. Tsai YT, Cheng PC, Pan TM. Applied Microbiology and Biotechnology. 2012;96(4):853-62. doi:10.1007/s00253-012-4407-3.

The Science Behind the Probiotic Strain Bifidobacterium Animalis Subsp. Lactis BB-12(®). Jungersen M, Wind A, Johansen E, et al. Microorganisms. 2014;2(2):92-110. doi:10.3390/microorganisms2020092.

Strain-Specific Therapeutic Potential of Lactiplantibacillus Plantarum: A Systematic Scoping Review. Chatsirisakul O, Leenabanchong N, Siripaopradit Y, et al. Nutrients. 2025;17(7):1165. doi:10.3390/nu17071165.

A Novel Approach to Lactiplantibacillus Plantarum: From Probiotic Properties to the Omics Insights. Echegaray N, Yilmaz B, Sharma H, et al. Microbiological Research. 2023;268:127289. doi:10.1016/j.micres.2022.127289.

Cardiometabolic Benefits of Lacticaseibacillus Paracasei 8700:2: A Randomized Double-Blind Placebo-Controlled Trial. Yang J, Huang J, Huang Z, et al. Clinical Nutrition (Edinburgh, Scotland). 2023;42(9):1637-1646. doi:10.1016/j.clnu.2023.07.017.

Potential Probiotic Properties of Exopolysaccharide-Producing Lacticaseibacillus Paracasei EPS DA-BACS and Prebiotic Activity of Its Exopolysaccharide. Lee MG, Joeng H, Shin J, et al. Microorganisms. 2022;10(12):2431. doi:10.3390/microorganisms10122431.

Beneficial Effects of Lactobacillus Paracasei Subsp. Paracasei NTU 101 and Its Fermented Products. Chiang SS, Pan TM. Applied Microbiology and Biotechnology. 2012;93(3):903-16. doi:10.1007/s00253-011-3753-x.

Probiotic Significance of Lactobacillus Strains: A Comprehensive Review on Health Impacts, Research Gaps, and Future Prospects. Shah AB, Baiseitova A, Zahoor M, et al. Gut Microbes. 2024 Jan-Dec;16(1):2431643. doi:10.1080/19490976.2024.2431643.

AGA Clinical Practice Guidelines on the Role of Probiotics in the Management of Gastrointestinal Disorders. Su GL, Ko CW, Bercik P, et al. Gastroenterology. 2020;159(2):697-705. doi:10.1053/j.gastro.2020.05.059.

 These statements have not been evaluated by the Food and Drug Administration.

These products are not intended to diagnose, treat, cure, or prevent any disease.

 Benefits:

• Supports digestion: Helps break down lactose and improves nutrient absorption.
• Boosts immune function: Enhances the gut barrier and modulates immune response.
• Balances gut flora: Helps restore healthy gut bacteria after antibiotic use.
• May reduce cholesterol: Some studies suggest it helps lower LDL (bad cholesterol).
• Improves bowel regularity: Supports healthy bowel movements and may relieve constipation.
• Supports lactose digestion: May improve tolerance to dairy products.
• Anti-inflammatory effects: Helps calm gut inflammation and supports gut lining.
• Enhances nutrient absorption: Promotes digestion of proteins and fats.
• Supports mood & brain health: May positively affect the gut-brain axis.
• Fights harmful bacteria: Produces antimicrobial substances.
• May relieve allergies: Shown to reduce symptoms of seasonal allergies.
• Gut barrier protection: Supports integrity of the intestinal lining.
• Promotes healthy aging: Linked to better gut health in older adults.

 How to Use:

 How: Take two (2) Veggie capsules once daily or as directed by a physician.

When:

Once daily

 Serving Size:

Two Capsules

 Ingredients:

• Lactobacillus Acidophilus (La-14)
• Bifidobacterium Lactis (Bl-04)
• Lactobacillus Plantarum (Lp-115)
• Lactobacillus Paracasei (Lpc-37)
• Hypromellose ( Veggie Capsule)
• Rice maltodextrin
• L-Leucine