Overview

Glucosamine is primarily used for supporting knee health. The benefits of glucosamine include:

Glucosamine sulfate and Chondroitin sulfate have been shown to reduce discomfort and improve function in patients with knee osteoarthritis (OA).

This is supported by several studies and meta-analyses, which indicate a marginally favorable effect on pain scores and some improvement in knee function.

Some studies suggest that glucosamine sulfate and chondroitin may slow the progression of joint space narrowing in knee OA, potentially delaying the need for joint replacement surgery.

This effect has been observed in long-term studies over a period of three years.

Glucosamine and Chondroitin are generally well-tolerated with a safety profile comparable to placebo.

They have fewer gastrointestinal side effects compared to non-steroidal anti-inflammatory drugs (NSAIDs).

Recent data suggest that regular consumption of glucosamine may support cardiovascular health, possibly due to its anti-inflammatory properties.

Chondroitin improves physical function in OA patients.

Studies have reported significant improvements in the Lequesne Index and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, which measure pain, stiffness, and physical function.

The European Medicines Agency (EMA) and the American College of Rheumatology (ACR) recommend chondroitin sulfate as a first-line treatment for knee OA due to its efficacy and safety profile.

 References:

1. Glucosamine as a Treatment for Osteoarthritis: What if It's True?. Conrozier T, Lohse T. Frontiers in Pharmacology. 2022;13:820971. doi:10.3389/fphar.2022.820971.
2. Effects of Glucosamine in Patients With Osteoarthritis of the Knee: A Systematic Review and Meta-Analysis. Ogata T, Ideno Y, Akai M, et al. Clinical Rheumatology. 2018;37(9):2479-2487. doi:10.1007/s10067-018-4106-2.
3. What Is the Current Status of Chondroitin Sulfate and Glucosamine for the Treatment of Knee Osteoarthritis?. Henrotin Y, Marty M, Mobasheri A. Maturitas. 2014;78(3):184-7. doi:10.1016/j.maturitas.2014.04.015.
4. Role of Glucosamine in the Treatment for Osteoarthritis. Reginster JY, Neuprez A, Lecart MP, Sarlet N, Bruyere O. Rheumatology International. 2012;32(10):2959-67. doi:10.1007/s00296-012-2416-2.
5. Glucosamine: A Review of Its Use in the Management of Osteoarthritis. Matheson AJ, Perry CM. Drugs & Aging. 2003;20(14):1041-60. doi:10.2165/00002512-200320140-00004.
6. 2019 American College of Rheumatology/­Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Kolasinski SL, Neogi T, Hochberg MC, et al. Arthritis Care & Research. 2020;72(2):149-162. doi:10.1002/acr.24131.
7. Chondroitin for Osteoarthritis. Singh JA, Noorbaloochi S, MacDonald R, Maxwell LJ. The Cochrane Database of Systematic Reviews. 2015;1:CD005614. doi:10.1002/14651858.CD005614.pub2.
8. Pharmaceutical-Grade Chondroitin Sulfate Is as Effective as Celecoxib and Superior to Placebo in Symptomatic Knee Osteoarthritis: The ChONdroitin Versus CElecoxib Versus Placebo Trial (CONCEPT). Reginster JY, Dudler J, Blicharski T, Pavelka K. Annals of the Rheumatic Diseases. 2017;76(9):1537-1543. doi:10.1136/annrheumdis-2016-210860.
9. Symptom and Structure Modification in Osteoarthritis With Pharmaceutical-Grade Chondroitin Sulfate: What's the Evidence?. Hochberg M, Chevalier X, Henrotin Y, Hunter DJ, Uebelhart D. Current Medical Research and Opinion. 2013;29(3):259-67. doi:10.1185/03007995.2012.753430.
10. Chondroprotection and the Prevention of Osteoarthritis Progression of the Knee: A Systematic Review of Treatment Agents. Gallagher B, Tjoumakaris FP, Harwood MI, et al. The American Journal of Sports Medicine. 2015;43(3):734-44. doi:10.1177/0363546514533777.
11. Highly Purified Chondroitin Sulfate: A Literature Review on Clinical Efficacy and Pharmacoeconomic Aspects in Osteoarthritis Treatment. Reginster JY, Veronese N. Aging Clinical and Experimental Research. 2021;33(1):37-47. doi:10.1007/s40520-020-01643-8.
12. Chondroitin Sulphate: A Focus on Osteoarthritis. Bishnoi M, Jain A, Hurkat P, Jain SK. Glycoconjugate Journal. 2016;33(5):693-705. doi:10.1007/s10719-016-9665-3.
13. Effects of Chondroitin Sulfate in the Pathophysiology of the Osteoarthritic Joint: A Narrative Review. Martel-Pelletier J, Kwan Tat S, Pelletier JP. Osteoarthritis and Cartilage. 2010;18 Suppl 1:S7-11. doi:10.1016/j.joca.2010.01.015.
14. What Is the Current Status of Chondroitin Sulfate and Glucosamine for the Treatment of Knee Osteoarthritis?. Henrotin Y, Marty M, Mobasheri A. Maturitas. 2014;78(3):184-7. doi:10.1016/j.maturitas.2014.04.015.

*These statements have not been evaluated by the Food and Drug Administration.

These products are not intended to diagnose, treat, cure, or prevent any disease.

Benefits:

• Joint Strength
• Cartilage Support
• Joint Mobility Support
• Bone Health

How to Use:

 How: Take three (3) capsules once daily before a meal or as directed by a physician.

When:

Once daily

Serving Size: 

Three (3) capsules

 Ingredients:

• Glucosamine Sulfate
• Chondroitin Sulfate
• Boswellia serrata
• Turmeric
• Quercetin
• Methionine
• Methylsulfonylmethane (MSM)
• Bromelain
• Hypromellose (Vegetable capsule)
• Rice Flour
• Contains Shellfish (Crayfish)