Overview

Type 1 Collagen: Type 1 collagen is the most abundant collagen in the human body and is primarily found in bones, skin, tendons, and ligaments. It provides tensile strength and structural support to these tissues. It is also involved in wound healing and bone mineralization.

Type 2 Collagen: Type 2 collagen is predominantly found in cartilage and is essential for maintaining the integrity and function of articular cartilage. It plays a critical role in joint health and is often used in supplements to support joint function and alleviate symptoms of osteoarthritis.

Type 3 Collagen: Type 3 collagen is a major component of the extracellular matrix in hollow organs such as blood vessels, uterus, and bowel. It is involved in the formation of reticular fibers and is crucial for the structural integrity of these organs. It also plays a role in wound healing and tissue repair.

Type 5 Collagen: Type 5 collagen is a minor component of the extracellular matrix but is essential for the regulation of collagen fibrillogenesis. It co-assembles with type 1 collagen and is involved in the formation of heterotypic fibrils, contributing to the structural integrity of tissues such as skin, cornea, and placenta.

Type 10 Collagen: Type 10 collagen is primarily found in hypertrophic cartilage during endochondral ossification, a process critical for bone development and growth. It is involved in the mineralization of cartilage and the transition of cartilage to bone.

These collagens have distinct roles in maintaining the structural and functional integrity of various tissues, and their supplementation can provide targeted benefits depending on the specific type and its associated tissue.

References:

1. Mechanism of Action of Collagen and Epidermal Growth Factor: A Review on Theory and Research Methods. Shahrajabian MH, Sun W. Mini Reviews in Medicinal Chemistry. 2024;24(4):453-477. doi:10.2174/1389557523666230816090054.
2. Type 1 Collagen: Synthesis, Structure and Key Functions in Bone Mineralization. Selvaraj V, Sekaran S, Dhanasekaran A, Warrier S. Differentiation; Research in Biological Diversity. 2024 Mar-Apr;136:100757. doi:10.1016/j.diff.2024.100757.
3. Collagen Supplementation for Joint Health: The Link Between Composition and Scientific Knowledge. Martínez-Puig D, Costa-Larrión E, Rubio-Rodríguez N, Gálvez-Martín P. Nutrients. 2023;15(6):1332. doi:10.3390/nu15061332.
4. Undenatured Type II Collagen and Its Role in Improving Osteoarthritis. Xu R, Wu J, Zheng L, Zhao M. Ageing Research Reviews. 2023;91:102080. doi:10.1016/j.arr.2023.102080.
5. Type III Collagen (COL3A1): Gene and Protein Structure, Tissue Distribution, and Associated Diseases. Kuivaniemi H, Tromp G. Gene. 2019;707:151-171. doi:10.1016/j.gene.2019.05.003.
6. Type v Collagen in Health, Disease, and Fibrosis. Mak KM, Png CY, Lee DJ. Anatomical Record (Hoboken, N.J. : 2007). 2016;299(5):613-29. doi:10.1002/ar.23330.
7. Type v Collagen Controls the Initiation of Collagen Fibril Assembly. Wenstrup RJ, Florer JB, Brunskill EW, et al. The Journal of Biological Chemistry. 2004;279(51):53331-7. doi:10.1074/jbc.M409622200.
8. Fibrillar Collagens. Bella J, Hulmes DJ. Sub-Cellular Biochemistry. 2017;82:457-490. doi:10.1007/978-3-319-49674-0_14.

Benefits:

• Provides tensile strength and structural support to tissues
  
  
• Maintains integrity and function of joints and cartilage
  
  
• Supports structural integrity of hollow organs
  
  
• Involved in wound healing and tissue repair
  
  
• Regulates collagen fibrillogenesis for tissue strength
  
  
• Contributes to bone mineralization and development
  
  
• Supports the transition of cartilage to bone
  
  
• Helps alleviate symptoms of osteoarthritis
  
  
• Enhances skin, organ, and bone health

 How to Use:

How: Take three (3) capsules once or twice daily or as directed by a physician.

When:

Once or twice daily

Serving Size:

Three (3) Capsules  

Ingredients:

• Bovine Collagen Peptides
• Hydrolyzed Chicken Collagen Peptides
• Pure Hydrolyzed Marine Collagen Peptides
• Eggshell Membrane Collagen Peptides
• Avian Sternum Collagen Peptides
• Gelatin Capsules
• Magnesium Stearate
• Contains: Egg, Fish (Cod)