Overview

Horny goat weed, also known as Epimedium, has been traditionally used in Chinese medicine for various health benefits. The primary active compound in horny goat weed is icariin, which has been studied for its pharmacological effects.

Sexual Dysfunction: Horny goat weed is commonly used to treat erectile dysfunction. Studies have shown that icariin can enhance erectile function by inhibiting phosphodiesterase type 5 (PDE5), similar to the mechanism of action of sildenafil (Viagra). Icariin has also demonstrated neurotrophic (nerve support) effects, which may contribute to improved sexual function.

Bone Health: Horny goat weed has been shown to possess anti-osteoporotic properties. It can promote bone formation and inhibit bone resorption, making it beneficial for individuals with osteoporosis.

Cardiovascular Health: Icariin has multiple atheroprotective functions, including attenuating DNA damage, correcting endothelial dysfunction, inhibiting smooth muscle cell proliferation, and reducing inflammatory responses.

Anti-Aging and Immune system: Horny goat weed has been reported to have anti-aging properties and can modulate immune function.

Longjack:Eurycoma longifolia, commonly known as Tongkat Ali or Longjack, is a traditional herbal medicine with several purported benefits, particularly in the context of male reproductive health. Clinical studies have demonstrated its potential to increase testosterone levels, which may contribute to improved sexual health and physical performance.

One study found that Eurycoma longifolia supplementation significantly increased testosterone levels in young males, suggesting benefits for muscle and strength gain. Another study highlighted its role in enhancing spermatogenesis by inhibiting phosphodiesterase and aromatase activity, which may improve fertility. Additionally, a trial involving men with androgen deficiency of aging males (ADAM) showed that Eurycoma longifolia supplementation, combined with concurrent training, improved erectile function and increased testosterone levels.

Furthermore, Eurycoma longifolia has been shown to improve quality of life and sexual well-being in men, with significant improvements in erectile function and libido. It is also considered a potential natural alternative to testosterone replacement therapy, with benefits for bone health and physical condition without significant side effects.

Overall, Eurycoma longifolia appears to offer benefits in enhancing testosterone levels, improving sexual function, and potentially aiding in muscle strength and fertility. However, more research is needed to fully understand its mechanisms and long-term safety profile.

L-Arginine: L-arginine has been studied for its potential benefits in treating erectile dysfunction (ED), particularly vasculogenic ED. L-arginine is a precursor to nitric oxide (NO), a key molecule involved in vasodilation and penile erection.

Additionally, combining L-arginine with phosphodiesterase type 5 inhibitors (PDE5i) like tadalafil has shown enhanced efficacy. A study on diabetic patients with ED demonstrated that the combination of L-arginine and tadalafil significantly improved IIEF scores and total testosterone levels compared to either treatment alone.

References:

1. Analysis of Pharmacological Mechanisms of Yinyanghuo as Treatment of Erectile Dysfunction With Network Pharmacology-Based Strategy. Yang X, Cui Y, Zhou Z, Zhao H, Zhang Y. Andrologia. 2021;53(2):e13943. doi:10.1111/and.13943.
2. Erectogenic and Neurotrophic Effects of Icariin, a Purified Extract of Horny Goat Weed (Epimedium Spp.) in Vitro and in Vivo. Shindel AW, Xin ZC, Lin G, et al. The Journal of Sexual Medicine. 2010;7(4 Pt 1):1518-28. doi:10.1111/j.1743-6109.2009.01699.x.
3. The Genus Epimedium: An Ethnopharmacological and Phytochemical Review. Ma H, He X, Yang Y, et al. Journal of Ethnopharmacology. 2011;134(3):519-41. doi:10.1016/j.jep.2011.01.001.
4. Icariin, an Anti-Atherosclerotic Drug From Chinese Medicinal Herb Horny Goat Weed. Fang J, Zhang Y. Frontiers in Pharmacology. 2017;8:734. doi:10.3389/fphar.2017.00734.
5. An Outline for the Pharmacological Effect of Icariin in the Nervous System. Jin J, Wang H, Hua X, et al. European Journal of Pharmacology. 2019;842:20-32. doi:10.1016/j.ejphar.2018.10.006.
6. Anti-Cancer Properties of the Naturally Occurring Aphrodisiacs: Icariin and Its Derivatives. Tan HL, Chan KG, Pusparajah P, et al. Frontiers in Pharmacology. 2016;7:191. doi:10.3389/fphar.2016.00191.
7. The Effect of Eurycoma Longifolia on the Regulation of Reproductive Hormones in Young Males. Chan KQ, Stewart C, Chester N, Hamzah SH, Yusof A. Andrologia. 2021;53(4):e14001. doi:10.1111/and.14001.
8. Eurycomanone, the Major Quassinoid in Eurycoma Longifolia Root Extract Increases Spermatogenesis by Inhibiting the Activity of Phosphodiesterase and Aromatase in Steroidogenesis.  Low BS, Choi SB, Abdul Wahab H, Das PK, Chan KL. Journal of Ethnopharmacology. 2013;149(1):201-7. doi:10.1016/j.jep.2013.06.023.
9. A 6-Month, Double-Blind, Placebo-Controlled, Randomized Trial to Evaluate the Effect of Eurycoma Longifolia (Tongkat Ali) and Concurrent Training on Erectile Function and Testosterone Levels in Androgen Deficiency of Aging Males (ADAM). Leitão AE, Vieira MCS, Pelegrini A, da Silva EL, Guimarães ACA. Maturitas. 2021;145:78-85. doi:10.1016/j.maturitas.2020.12.002.
10. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma Longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Ismail SB, Wan Mohammad WM, George A, et al. Evidence-Based Complementary and Alternative Medicine : eCAM. 2012;2012:429268. doi:10.1155/2012/429268.
11. Phytoandrogenic Properties of Eurycoma Longifolia as Natural Alternative to Testosterone Replacement Therapy. George A, Henkel R. Andrologia. 2014;46(7):708-21. doi:10.1111/and.12214.
12.  Long-Term High-Dose L-Arginine Supplementation in Patients With Vasculogenic Erectile Dysfunction: A Multicentre, Double-Blind, Randomized, Placebo-Controlled Clinical Trial. Menafra D, de Angelis C, Garifalos F, et al. Journal of Endocrinological Investigation. 2022;45(5):941-961. doi:10.1007/s40618-021-01704-3.
13. The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis. Rhim HC, Kim MS, Park YJ, et al. The Journal of Sexual Medicine. 2019;16(2):223-234. doi:10.1016/j.jsxm.2018.12.002.
14. Daily Oral L-Arginine Plus Tadalafil in Diabetic Patients With Erectile Dysfunction: A Double-Blinded, Randomized, Controlled Clinical Trial. El Taieb M, Hegazy E, Ibrahim A. The Journal of Sexual Medicine. 2019;16(9):1390-1397. doi:10.1016/j.jsxm.2019.06.009.

Benefits:

• Horny Goat Weed (Epimedium)
• Supports erectile function by inhibiting PDE5
  
• Supports bone health and prevents osteoporosis
  
• Promotes cardiovascular health by protecting blood ves
• Supports nerve heal
• mune system supportAnti-aging support
• Tongt Ali (Eurycoma longifolia):
•  Enhances testosterone levels naturally
  
• Enhances sexual health and supports erectile function
  
•   Supports fertility by boosting sperm production
  
•  Supports muscle strength and physical performance
  
• Promotes bone health and overall physical well-being
  

How to Use:

How: Take two (2) capsules once daily or as directed by a physician.

When:

Once daily

Serving Size:

Two (2) Capsules

 Ingredients:

• Horny Goat Weed
• Maca Powder
• L-Phenylalanine
• Polypody Vulgare
• Longjack Root
• Saw Palmetto Powder
• Muira Puama Powder
• L-Arginine
• Asian Ginseng Powder
• Gelatin Capsules
• Rice Flour
• Vegetable Magnesium Stearate